vitamin D binding protein precursor (353-363) [Homo sapiens]
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
人维生素D结合蛋白(HDBP)又被称为Gcglobulin,是由肝脏合成的一种丰富的、多功能的并且具有高度多态性的血清糖蛋白1。DBP是维生素D固醇类物质的主要血清转运蛋白2,高亲和力的结合并隔绝肌动蛋白单体3,4,存在于多种细胞的细胞膜上,包括B淋巴细胞、T淋巴细胞和胎盘的细胞滋养细胞。
DPB是一种分泌蛋白质,因此推测其具有一个信号序列。通过对cDNA和hDBP的氨基末端多肽进行序列比对,预测建立了成熟血清蛋白氨基末端的模型8。
C61H99N17O16
Figure1. Structure of Vitamin D binding protein
Figure2. Formula of Vitamin D binding protein precursor (353-363)
参考文献:
1.Haddad, J. G. 1979. Transport of vitamin D metabolites. Clin. Orthop. Relat. Res. 142:249-274.
2.Daiger, S. P., M. S. Schanfield, and L. L. Cavalli-Sforza. 1975. Group specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc. Natl. Acad. Sci. USA. 72:2076-2080.
3.Cooke, N. E., J. Walgate, and J. G. Haddad. 1979. Human serum binding protein for vitamin D and its metabolites. I. Physicochemical and immunological identification in human tissues. J. Biol. Chem. 254: 5965-5971.
4.Van Baelen, H., R. Bouillon, and P. DeMoor. 1980. Vitamin D binding protein (Gc-Globulin) binds actin. J. Biol. Chem. 255:2270-2272.
5.Petrini, M., D. L. Emerson, and R. M. Galbraith. 1983. Linkage between surface immunoglobulin and cytoskeleton of B lymphocytes may involve Gc protein. Nature (Lond.). 306:73-74.
6.Petrini, M., R. M. Galbraith, D. L. Emerson, A. E. Nel, and P. Arnaud. 1985. Structural studies of T lymphocyte Fc receptors. J. Biol. Chem. 260:1804-1810.
7.Nestler, J. E., E. Lange, J. McLeod, H. J. Kliman, and J. F. Strauss. 1985. Detection of vitamin D binding protein (DBP) in human cytotrophoblasts. Seventh Annual American Societyfor Bone and Mineral Research. Wash. DC. 266a. (Abstr.).
8.Svasti, J., A. Kurosky, A. Bennett, and B. H. Bowman. 1979. Molecular basis for the three major forms of human serum vitamin D binding protein (group specific component). Biochemistry. 18:1611-1617.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 1326.54 |
Formula | C61H99N17O16 |
Synonyms | H2N-Arg-Thr-His-Leu-Pro-Glu-Val-Phe-Leu-Ser-Lys-OH |
Solubility | ≥132.7 mg/mL in DMSO; ≥46.8 mg/mL in EtOH; ≥67.4 mg/mL in H2O |
SDF | Download SDF |
Canonical SMILES | NC(CCCNC(N)=N)C(NC(C(C)O)C(NC(CC1=CN=CN1)C(NC(CC(C)C)C(N(CCC2)C2C(NC(CCC(O)=O)C(NC(C(C)C)C(NC(CC3=CC=CC=C3)C(NC(CC(C)C)C(NC(CO)C(NC(CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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