(±)-Octanoylcarnitine chloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
(±)-Octanoylcarnitine chloride is a homolog of acetylcarnitine chloride. Acylcarnitines, the acetyl derivatives of carnitine, are important intermediates in lipid metabolism, required for the transport of long-chain fatty acids into mitochondria for β-oxidation and ATP production, and for the removal of excess short-chain and medium-chain fatty acids. (±)-Octanoylcarnitine has been shown to decrease the oxidation rate of the branched-chain 2-oxo acids 4-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate in isolated rat muscle mitochondria in the presence of carnitine, but octanoyl-L-carnitine increases oxidation of 4-methyl-2-oxopentanoate in the absence of carnitine. In addition, (±)-octanoylcarnitine, along with malate, has been used as a mitochondrial respiration substrate to evaluate the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of ADP.
References:
1. Zhang Y, Ma Q, Bai X. Effects of dietary acetyl-L-carnitine on meat quality and lipid metabolism in arbor acres broilers. Asian-Australasian Journal of Animal Sciences, 2010, 23(12): 1639-1644.
2. Veerkamp JH, van Moerkerk HT, Wagenmakers AJ. Interaction of short-chain and branched-chain fatty acids and their carnitine and CoA esters and of various metabolites and agents with branched-chain 2-oxo acid oxidation in rat muscle and liver mitochondria. International Journal of Biochemistry, 1985, 17(9): 967-974.
3. Toleikis A, Trumbeckaite S, Liobikas J, et al. Fatty Acid Oxidation and Mitochondrial Morphology Changes as Key Modulators of the Affinity for ADP in Rat Heart Mitochondria. Cells, 2020, 9(2): 340.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 323.86 |
Cas No. | 14919-35-8 |
Formula | C15H30ClNO4 |
Solubility | ≥36.9 mg/mL in DMSO; ≥18.6 mg/mL in EtOH; ≥37.4 mg/mL in H2O |
Chemical Name | 3-carboxy-N,N,N-trimethyl-2-(octanoyloxy)propan-1-aminium chloride |
SDF | Download SDF |
Canonical SMILES | O=C(CCCCCCC)OC(CC(O)=O)C[N+](C)(C)C.[Cl-] |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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