Tenovin-1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Tenovin-1,是在细胞表面上发现的一个小分子,是一种具有生物活性的p53的激活剂。Tenovin-1可以提高p53蛋白,p53下游目标蛋白p21CIP/WAF1和mRNA的水平,并防止mdm2介导的p53的退化,使之对于p53的合成没有影响。Tenovin-1也可以对sirtuin蛋白家族的两个重要的人SirT1和SirT2蛋白产生抑制作用。由于Tenovin-1溶解度很低,所以发现了一个改进的和水溶性的tenovin-1来降低人SirT1和SirT2的肽脱乙酰酶活性,tenovin-1对SirT1和SirT2的IC50值分别为21 μM和10 μM。
参考文献:
[1]. Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. doi: 10.1016/j.ccr.2008.03.004.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 369.5 |
Cas No. | 380315-80-0 |
Formula | C20H23N3O2S |
Solubility | insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO with gentle warming |
Chemical Name | N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide |
SDF | Download SDF |
Canonical SMILES | CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
描述 | Tenovin-1用于防止MDM2介导的p53的降解。 | |||||
靶点 | p53 | |||||
IC50 |
质量控制和MSDS
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