SR59230A
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SR59230A 是一种有效的选择性β3-肾上腺素能受体拮抗剂（β3 IC50 = 40 nM，β1 IC50 = 408 nM，β2 IC50 = 648 nM），并具有穿透血脑屏障的能力。SR59230A对β3-AR的特异性拮抗作用，能抑制NB生长和肿瘤进展，通过特异性阻断SK2/S1P2信号，在体内和体外实现从干细胞转变为细胞分化。SR 59230A浓度依赖性地抵消了NE刺激下的，融合棕色脂肪细胞中，解偶联蛋白基因的合成，这主要是选择性刺激β3肾上腺素受体的结果。在载体之后，MDMA产生了缓慢发展的过高热，在注射后 130 分钟达到最高上升1.8 摄氏度。低浓度的SR59230A（0.5 mg x kg（-1））对MDMA引起的缓慢发展的过高热，产生较小但显著的衰减。高浓度的SR59230A（5 mg x kg（-1））显示对MDMA有显著的早期低温反应，α（1）-肾上腺素受体拮抗剂prazosin模拟了这种作用。
1. Bexis S, et al. Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. Br J Pharmacol. 2009 Sep;158(1):259-66.
2. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Mol Pharmacol. 1996 Jan;49(1):7-14.
3. Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. Oncogene. 2020 Jan;39(2):368-384.
| Storage | Store at -20°C |
| M.Wt | 415.48 |
| Cas No. | 174689-39-5 |
| Formula | C23H29NO6 |
| Solubility | ≥23.5 mg/mL in DMSO |
| Chemical Name | (S)-1-(2-ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol oxalate |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(O)=O)O.CCC1=CC=CC=C1OC[C@@H](O)CN[C@H]2CCCC3=C2C=CC=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
