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Psoralidin

补骨脂定
Catalog No.
C4962
凋亡诱导剂
组合的产品项目
规格价格库存 数量
5mg
¥ 654.00
Ship with 10-15 days
10mg
¥ 1,181.00
Ship with 10-15 days
25mg
¥ 2,618.00
Ship with 10-15 days
100mg
¥ 8,181.00
Ship with 10-15 days

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背景

Psoralidin is a dual inhibitor of COX-2 and 5-LOX. Psoralidin, a coumestan derivative isolated from seed of Psoralea corylifolia, has been widely used in traditional medicine for bleeding, pollakiuria, enuresis, vitiligo, and psoriasis. Psoralidin shows a variety of biological activities such as anti-cancer, anti-bacterial, anti-oxidant, anti-depressant activities and regulation of insulin signaling [1].

Psoralidin (100 μM) inhibited COX-2 in IR-irradiated normal lung fibroblasts in HFL-1 and MRC-5 cells [1]. Psoralidin significantly inhibited IR-induced NF-κB-luciferase activity. Psoralidin inhibited the IR-induced COX-2 expression and PGE2 production through regulation of PI3K/Akt and NF-κB pathway. Also, psoralidin blocked IR-induced LTB4 production through direct interaction with 5-lipoxygenase activating protein (FLAP) in 5-LOX pathway. Psoralidin significantly attenuated IR-induced fibroblast migration [1]. Psoralidin inhibited LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways [2]. Psoralidin enhanced TRAIL-induced apoptosis in HeLa cells through increased expression of TRAIL-R2 death receptor and depolarization of mitochondrial membrane potential [3].

In male BALB/c strain mice (eight weeks, average weight 22–25 g), psoralidin (5 mg/kg) suppressed IR-induced expression of pro-inflammatory cytokines (TNF-α, TGF-β, IL-6 and IL-1 α/β) and ICAM-1 [1].

References:
[1] Yang H J, Youn H S, Seong K M, et al.  Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation[J]. Biochemical pharmacology, 2011, 82(5): 524-534.
[2] Chiou W F, Don M J, Liao J F, et al.  Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways[J]. European journal of pharmacology, 2011, 650(1): 102-109.
[3] Bronikowska J, Szliszka E, Jaworska D, et al.  The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)[J]. Molecules, 2012, 17(6): 6449-6464.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt336.3
Cas No.18642-23-4
FormulaC20H16O5
Solubility≤14mg/ml in DMSO;14mg/ml in dimethyl formamide
Chemical Name3,9-dihydroxy-2-(3-methyl-2-buten-1-yl)-6H-benzofuro[3,2-c][1]benzopyran-6-one
SDFDownload SDF
Canonical SMILESOC1=CC(O2)=C(C=C1)C3=C2C4=C(OC3=O)C=C(O)C(C/C=C(C)/C)=C4
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质量控制

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批次:

化学结构

Psoralidin