Tauroursodeoxycholic Acid
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 500mg | ￥531.00 | 现货 | |
| 1g | ￥1016.00 | 现货 | |
| 5g | ￥2127.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Tauroursodeoxycholic acid (TUDCA) is a taurine conjugate product of ursodeoxycholic acid, which can be used as a mitochondrial stabilizer and anti-apoptotic agent.
In endoplasmic reticulum stress conditions, TUDCA treatment of MSCs (mesenchymal stem cells) reduces the activation of ER stress-associated proteins and inhibits the dissociation between GRP78 and PERK, thereby reducing endoplasmic reticulum stress Mediated cell death.
In a murine hindlimb ischemia model, TUDCA-treated mesenchymal stem cells (MSCs) transplantation can increase blood perfusion ratio, promote blood vessel formation, and improve the survival rate of transplanted cell more than untreated MSC transplantation does.
Reference:
[1]. Yoon Y M, Lee J H, Yun S P, et al. Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein. Scientific Reports, 2016, 6(1): 39838.
产品性质
| 物理外观 | Solid |
| CAS号 | 14605-22-2 |
| 分子式 | C26H45NO6S |
| 分子量 | 499.7 |
| 小分子别名 | Tauroursodeoxycholate |
| 化学名称 | 2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid |
| 溶解度 | ≥50 mg/mL in DMSO; ≥4.8 mg/mL in H2O with ultrasonic; ≥55.7 mg/mL in EtOH |
| SMILES | C[C@H](CCC(NCCS(O)(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 牛磺脱氧胆酸（Tauroursodeoxycholate）是一种内质网（ER）应激抑制剂。Tauroursodeoxycholate 能明显降低 caspase-3 和 caspase-12 等凋亡分子的表达。牛磺脱氧胆酸还能抑制 ERK。 |
| 靶点 | Mitochondrial Metabolism |
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