Myelin Basic Protein (87-99) GUINEA PIG, HUMAN
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
碱性蛋白是中枢神经系统髓鞘的主要结构蛋白，占总蛋白的30％(1)。
使用全长MBP筛选T淋巴细胞系，通常仅识别1-3免疫显性表位(Offner et al., 1987, 1988; Trotter et al., 1987: Bourdctte et al., 1988; McCarron and McFarlin, 1988)，并且这些MBP免疫表位经常是致脑炎性的(Vandenbark et al., 1985b, 1989; Hashim et al., 1991)。因此，免疫显性表位MBP的鉴定，为鉴定未识别的MBP致脑炎表位提供了一种体外研究方法(2)。
多发性硬化症（MS）的发生机制尚不清楚，但是认为T细胞介导的自身免疫过程参与了这个过程。髓鞘碱性蛋白（MBP）是一种潜在的靶抗原，在易感动物中，它可以诱导实验性过敏性脑脊髓炎（EAE）。MBP的致脑炎表位在不同的敏感菌中存在差异，与MHC II类基因型相关(3)。
Figure1. Structure of Myelin Basic Protein
Figure2. Formula of Myelin Basic Protein (87-99)
参考文献：
1. EYLAR, E. H., in L.Rowland (Editor), Immunologic disorders of the nervous system, Academic Press, New York, 1971, Chapter 5.
2. Jones et al (1992) the synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 37 203
3. Fritz, R., and D.E. McFarlin . 1989. Encephalitogenic epitopes 10. Richert, J., E.D. Robinson, G.E . Deibler, R.E. Martenson, of myelin basic protein. Chem. Immunol. 46:101.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1555.8 |
| Cas No. | 118506-26-6 |
| Formula | C74H114N20O17 |
| Synonyms | Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro |
| Solubility | ≥15.97 mg/mL in EtOH with gentle warming and ultrasonic; ≥50.7 mg/mL in H2O; ≥77.8 mg/mL in DMSO |
| Chemical Name | Myelin Basic Protein (87-99) |
| SDF | Download SDF |
| Canonical SMILES | CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)O)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C(C(C)C)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
