MC 1046
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MC 903是一种有效的细胞分化诱导剂，可以抑制表达1,25(OH)2D3受体的细胞增殖以及合成DNA。MC 1046，Calcipotriol（MC 903）的代谢物，是一种新型的维生素D3生理活性代谢物的类似物。
体外：探讨了两个主要MC 903代谢物（MC 1046和MC 1080）对U937细胞的生物学作用。结果表明，上述代谢物的作用比母体化合物的弱100倍以上[1]。
体内：MC 903是一种新型的1,25(OH)2D3生理活性代谢物类似物。MC 903具有类似于1,25(OH)2D3的体外细胞增殖以及细胞分化作用，但MC 903对体内钙代谢的作用较1,25(OH)2D3的弱100 ~ 200倍。此外，大鼠研究表明，MC 903对增生性疾病有效，形成无活性代谢物并被快速消除，上述特性使MC 903适用于局部牛皮癣治疗[1]。
临床试验：MC 1046及其类似物没有可用的临床数据。
参考文献：
[1] Kissmeyer AM, Binderup L. Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3. Biochem Pharmacol. 1991;41(11):1601-6.
| Storage | Store at -20°C |
| M.Wt | 410.59 |
| Cas No. | 126860-83-1 |
| Formula | C27H38O3 |
| Synonyms | Impurity A of Calcipotriol |
| Solubility | Soluble in DMSO |
| Chemical Name | (E,4R)-4-[(1R,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-cyclopropylpent-2-en-1-one |
| SDF | Download SDF |
| Canonical SMILES | CC(C=CC(=O)C1CC1)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | MC 1046是Calcipotriol的代谢物。 | |||||
| 靶点 | ||||||
| IC50 | ||||||
化学结构
![vitamin D binding protein precursor (353-363) [Homo sapiens]](/pub/media/prod_images/a/1/a1099.png)
