Lauric Acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Lauric acid是具有12-碳骨架的一种饱和中链脂肪酸,天然存在于各种植物和动物脂肪和油中,是棕榈仁油和椰子油的主要组分。
体外:先前研究表明,与丁酸盐相比,lauric acid可诱导Caco-2和IEC-6细胞凋亡。此外,在Caco-2细胞中,lauric acid降低GSH利用度并产生ROS。机理研究表明,lauric acid减少G0/G1期中的Caco-2和IEC-6细胞,并将细胞停滞在S和G2/M期。此外,研究发现丁酸盐保护IEC-6细胞免受ROS诱导的损伤,而lauric acid与丁酸盐相比诱导更高水平的ROS [1]。
体内研究:小鼠体内研究发现,表皮给药和皮内注射lauric acid都可有效减少小鼠耳中定居的痤疮丙酸杆菌的数量,从而缓解痤疮丙酸杆菌引起的肉芽肿炎症和耳肿胀[2]。
临床试验:先前临床研究表明,lauric acid摄入不会引起恶心或腹胀。lauric acid对早餐能量摄入没有影响,在摄入lauric acid后午餐能量摄入显著降低。此外,与对照相比,摄取6 g lauric acid后总能量摄入(早餐+午餐+lauric acid剂量)较少[3]。
参考文献:
[1] Fauser JK,Matthews GM,Cummins AG,Howarth GS. Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress. Chemotherapy.2013;59(3):214-24.
[2] Nakatsuji T,Kao MC,Fang JY,Zouboulis CC,Zhang L,Gallo RL,Huang CM. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol.2009 Oct;129(10):2480-8.
[3] Kate L. Feltrin et al. Acute oral administration of lauric acid reduces energy intake in healthy males. e-SPEN Journal. 2014 April; 9 (2): e69–e75
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 200.32 |
Cas No. | 143-07-7 |
Formula | C12H24O2 |
Solubility | insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥40.4 mg/mL in EtOH |
Chemical Name | dodecanoic acid |
SDF | Download SDF |
Canonical SMILES | CCCCCCCCCCCC(O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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