骆驼蓬碱 (Harmine) ，分离自骆驼蓬种子，是β-carboline家族的一种生物碱，通过对Wnt信号通路的抑制可以调节PPARγ的表达。它还选择性地与MAO-A结合，可逆地抑制单胺氧化酶A (MAO-A)，但对MAO-B没有抑制作用[3]。

Harmine对肝癌细胞具有严重的细胞毒性，是一种很有前景的抗癌药物[4]。

参考文献：
[1] Smith B, Medda F, Gokhale V, et al. Recent Advances in theDesign, Synthesis, and BiologicalEvaluation of Selective DYRK1A Inhibitors: A New Avenue for a DiseaseModifying Treatment of Alzheimer’s?[J]. Acs Chemical Neuroscience, 2012, 3(11):857-72.
[2] Waki H, Park K W, Mitro N, et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.[J]. Cell Metabolism, 2007, 5(5):357-370.
[3] Ginovart N, Meyer J H, Boovariwala A, et al. Positron emission tomography quantification of |[lsqb]|11C|[rsqb]|-harmine binding to monoamine oxidase-A in the human brain[J]. Journal of Cerebral Blood Flow & Metabolism Official Journal of the International Society of Cerebral Blood Flow & Metabolism, 2006, 26(3):330-44.
[4] Zhang L, Zhang F, Zhang W, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells[J]. Cancer Biology & Therapy, 2015, 16(11):1585-1592.