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Erythromycin A enol ether

红霉素 A 烯醇醚
Catalog No.
C3019
肽激素胃动素的β转角模拟物
组合的产品项目
规格价格库存 数量
5mg
¥ 2,979.00
Ship with 10-15 days
10mg
¥ 4,387.00
Ship with 10-15 days

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A

背景

Erythromycin A enol ether, also known as 8,9-anhydroerythromycin A 6,9 hemiketal, is a kind of catabolite of erythromycin A without its antibiotic properties.

Erythromycin A enol ether functions as a β-turn mimic of the peptide hormone motilin which leads to duodenal contractions. Erythromycin A enol ether is also the agent of gastrointestinal (GI) distress [1].

Motilin is a kind of polypeptide hormone with 22-amino acid belonging to the motilin family. Motilin could increase the migrating myoelectric complex of gastrointestinal motility, and stimulate the pepsin production. Motilin could also improve peristalsis in the small intestine and empty the gut for the next meal. Besides, motilin could facilitate the release of somatostatin and pancreatic polypeptide.

In Vitro: No data available.

In Vivo: No data available.

Clinical trial: No data available.

Reference:
[1] Steinmetz W E, Shapiro B L, Roberts J J, et al.  The structure of erythromycin enol ether as a model for its activity as a motilide.[J]. Journal of Medicinal Chemistry, 2002, 45(22): 4899-4902.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt715.9
Cas No.33396-29-1
FormulaC37H65NO12
SynonymsBRL 46357ER,EM-201
Solubility≤30mg/ml in DMSO;15mg/ml in dimethyl formamide
Chemical Name8,9-didehydro-9-deoxo-6-deoxy-6,9-epoxy-erythromycin
SDFDownload SDF
Canonical SMILESO=C1[C@@H]([C@H]([C@@H]([C@]([H])([C@]2(CC(C)=C([C@@H]([C@H]([C@@](C)([C@H](O1)CC)O)O)C)O2)C)O[C@]3([C@@H]([C@H](C[C@H](O3)C)N(C)C)O)[H])C)O[C@@]4(O[C@H]([C@@H]([C@@](C)(C4)OC)O)C)[H])C
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质量控制

质量控制和MSDS

批次:

化学结构

Erythromycin A enol ether