DJ-V-159
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
DJ-V-159 是G蛋白偶联受体家族C组6A(GPRC6A)的激动剂。DJ-V-159激活转染GPRC6A的HEK-293中的ERK，但不激活未转染的HEK-293细胞，其效力类似于L-Arg。此外，DJ-V-159剂量依赖性地刺激表达GPRC6A的HEK-293细胞中的cAMP产生，在培养基中达到0.2 nM浓度的响应。DJ-V-159刺激小鼠β细胞MIN-6细胞中的胰岛素分泌。腹腔注射10 mg/kg后，DJ-V-159在60分钟和90分钟时将野生型小鼠的血糖水平分别降低43.6%和41.9%。小鼠可以忍受这种短期接触 DJ-V-159的情况，而没有任何明显的副作用[1]。
参考文献：
[1]. Pi M, Kapoor K, Ye R, Hwang DJ, Miller DD, Smith JC, Baudry J, Quarles LD. Computationally identified novel agonists for GPRC6A. PLoS One. 2018 Apr 23;13(4):e0195980. doi: 10.1371/journal.pone.0195980. PMID: 29684031; PMCID: PMC5912754.
| Storage | Store at -20°C |
| M.Wt | 502.38 |
| Cas No. | 2253744-53-3 |
| Formula | C24H12F6N4O2 |
| Solubility | ≥12.53 mg/mL in DMSO with ultrasonic |
| Chemical Name | N1,N3-bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=CC(C(NC2=CC(C(F)(F)F)=C(C#N)C=C2)=O)=CC=C1)NC3=CC(C(F)(F)F)=C(C#N)C=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
