Cevimeline
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cevimeline是一种毒蕈碱受体激动剂，尤其作用于M1和M3受体。[1]
Cevimeline已被批准用于通过激活副交感神经系统的M 3受体，治疗口干症状。20毫克每天三次的Cevimeline对于改善眼干症状是有效的和安全的[2]。Cevimeline在大于1 μM浓度时可增加腮腺腺泡细胞的细胞内Ca+水平，并通过毒蕈碱受体增强大鼠兴奋性，因而Cevimeline通过刺激唾液腺分泌缓解口干症状。Cevimeline具有较长的流涎持续时间[3]。Cevimeline对阿尔茨海默病起作用。1 mg/kg的Cevimeline降低脑脊液（CSF）中Aβ（1-40）水平而不改变兔α-APPs，并显著降低AD患者的CSF Aβ。[4]
参考文献：
1. F. B. Vivino, I. Al-Hashimi, Z. Khan, F. G. LeVeque, P. L. Salisbury, 3rd, T. K. Tran-Johnson, C. C. Muscoplat, M. Trivedi, B. Goldlust and S. C. Gallagher, Arch Intern Med 1999, 159, 174-181.
2. M. Ono, E. Takamura, K. Shinozaki, T. Tsumura, T. Hamano, Y. Yagi and K. Tsubota, Am J Ophthalmol 2004, 138, 6-17.
3. K. Ono, T. Inagaki, T. Iida, R. Hosokawa and K. Inenaga, J Med Invest 2009, 56 Suppl, 375.
4. A. Fisher, Z. Pittel, R. Haring, N. Bar-Ner, M. Kliger-Spatz, N. Natan, I. Egozi, H. Sonego, I. Marcovitch and R. Brandeis, J Mol Neurosci 2003, 20, 349-356.
| Storage | Store at -20°C |
| M.Wt | 199.32 |
| Cas No. | 107233-08-9 |
| Formula | C10H17NOS |
| Synonyms | Evoxac |
| Solubility | Soluble in DMSO |
| Chemical Name | (2R,5R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane] |
| SDF | Download SDF |
| Canonical SMILES | CC1OC2(CN3CCC2CC3)CS1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
