CB-103
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
CB-103 是一种口服活性的 Notch 转录激活复合物的抑制剂。CB-103可在果蝇和小鼠中产生Notch功能丧失的表型，并抑制人类乳腺癌和白血病异种移植瘤的生长[1]。CB-103在人急性T淋巴细胞白血病癌细胞系中显示出阻断NOTCH信号的能力，并在GSI抗性T-ALL细胞系中表现出抗肿瘤的功效[2]。CB-103抑制GSI/Mab抗性三阴性乳腺癌的生长，并在人类T-ALL和小鼠乳腺肿瘤的异种移植模型中表现出抗肿瘤活性[3]。
参考文献：
[1]. Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, González-Gaitán M, Arsenijevic Y, Zoete V, Aster JC, Bourquin JP, Radtke F. Pharmacological disruption of the Notch transcription factor complex. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16292-16301. doi: 10.1073/pnas.1922606117. Epub 2020 Jun 29. PMID: 32601208; PMCID: PMC7368267.
[2]. R.Lehal, et al. Development of a novel first-in-class oral inhibitor of the NOTCH pathway.
[3]. Rajwinder Lehal, et al. Non clinical pharmacology, pharmacokinetics and safety profiling of CB-103: A novel first-in-class small molecule inhibitor of the NOTCH pathway.
| Storage | Store at -20°C |
| M.Wt | 242.32 |
| Cas No. | 218457-67-1 |
| Formula | C15H18N2O |
| Solubility | ≥26.2 mg/mL in DMSO |
| Chemical Name | 6-(4-(tert-butyl)phenoxy)pyridin-3-amine |
| SDF | Download SDF |
| Canonical SMILES | NC1=CC=C(N=C1)OC2=CC=C(C(C)(C)C)C=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
