Adenosine amine congener
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Adenosine amine congener （ADAC）是一种选择性A1腺苷受体激动剂，可改善噪声和顺铂诱导的耳蜗损伤。与对照组相比，在噪声暴露后的时间间隔内腹腔注射 ADAC (100 μg/kg/天) 时，听力阈值的恢复显着提高。此外，ADAC对大鼠噪声性耳蜗损伤的剂量依赖性的救援作用也得到了研究，并建立了治疗时间窗。 ADAC在噪声暴露后的前24小时内，以>50 μg/kg的剂量最有效，可提供高达21 dB的保护（平均8-28 kHz）。药代动力学研究表明，静脉注射ADAC后，血浆中ADAC的半衰期较短（5分钟），且未检测到降解产物。
1. Vlajkovic S M , Lee K H , Wong A C Y , et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signalling, 2010, 6(2):p.273-281.
2. Hao C , Telang R S , Sreevalsan S , et al. Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration. BioMed Research International, 2017, 2017:1-8.
| Storage | Store at -20°C |
| M.Wt | 576.6 |
| Cas No. | 96760-69-9 |
| Formula | C28H32N8O6 |
| Solubility | ≥25.1 mg/mL in DMSO |
| Chemical Name | N-(2-aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | OC[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O1)N2C=NC3=C2N=CN=C3NC4=CC=C(CC(NC5=CC=C(CC(NCCN)=O)C=C5)=O)C=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
