Ac-Endothelin-1 (16-21), human
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
内皮素-1（ET-1）是内皮素家族主要的多肽，在血管和非血管组织参与多种生物学过程，包括心脏、肾脏和中枢神经系统。
在细胞水平，ET-1的作用是由ETA和ETB两个特定受体亚型介导的，这两者与磷脂酶C（PLC）功能上相耦合。
ET家族多肽的C-末端片段是高度保守序列，因为C末端片段仅激活ETB，可以用它来区分ETA和ETB的两个ET受体亚型。
参考文献：
1. Rubanyi, G. M., and M. A. Polokoff. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 46: 325–415, 1994
2. Simonson MS. Endothelins: multifunctional renal peptides. Physiol Rev 1993; 73: 375–411.
3. PM Vanhoutte Endothelin-1. A matter of life and breath, Nature, 368 (1994), pp. 693–694
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 837.96 |
| Formula | C41H59N9O10 |
| Synonyms | Ac-His-Leu-Asp-Ile-Ile-Trp-OH |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥83.8 mg/mL in DMSO with gentle warming |
| SDF | Download SDF |
| Canonical SMILES | O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](C)CC)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CC1=CC(C=CC=C2)=C2N1)C(O)=O)=O)=O)=O)=O)[C@H](CC3=CNC=N3)NC(C)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
