Proteasome
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
- A2612 MG-1151 CitationTarget: ProteasomeSummary: 蛋白酶体抑制剂
- A4010 Salinosporamide A (NPI-0052, Marizomib)Target: ProteasomeSummary: 20S蛋白酶体抑制剂
- A4011 ONX-0914 (PR-957)6 CitationTarget: ProteasomeSummary: 免疫蛋白酶体(immunoproteasome)抑制剂
- A2585 MG-13226 CitationTarget: ProteasomeSummary: 细胞通透性的、可逆性的蛋白酶体抑制剂。
- A2606 Epoxomicin25 Citation中文名: 环氧酶素Summary: 蛋白酶体抑制剂
- A2583 Lactacystin (Synthetic)1 Citation中文名: 蛋白酶体抑制剂Target: ProteasomeSummary: 蛋白酶体抑制剂
- A4014 Artemether (SM-224)中文名: 蒿甲醚Summary: 半合成的青蒿素衍生物
- A4009 CEP-187701 CitationSummary: 蛋白酶体抑制剂
- A4008 MLN2238中文名: 伊沙佐米Summary: 20S蛋白酶体β5位点抑制剂
- A2578 Clasto-Lactacystin β-lactoneTarget: ProteasomeSummary: 蛋白酶体抑制剂