ZLN005
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ZLN005是一种新型的PGC-1α转录调控子[1].
过氧化物酶体增殖体激活受体γ共激活因子-1α(PGC-1α)是一种诱导型共调节因子,可调节能量代谢.PGC-1α调控葡萄糖和脂肪酸代谢\线粒体生物发生等等.PGC-1α失调与胰岛素抵抗和2型糖尿病有关[1].
ZLN005是一种新型的PGC-1α转录调控子.在PGC-1α启动子报告试验中,ZLN005可有效地抑制荧光素酶.在L6肌管中,ZLN005可剂量依赖地增加PGC-1α的mRNA水平.ZLN005(10 μM)可提高细胞色素c氧化酶5b(cox5b)\乙酰辅酶A氧化酶\雌激素相关受体α(ERRα)\NRF1和GLUT4的mRNA水平.ZLN005(20 μM)可以剂量依赖的方式分别提高1.8倍和1.28倍的葡萄糖吸收和棕榈酸氧化.在转染PGC-1α siRNA的L6肌管中,ZLN005刺激的棕榈酸氧化和PGC-1α基因表达被阻断.在L6肌管中,ZLN005可提高AMPK和乙酰辅酶A羧化酶(ACC)的磷酸化[1].
在db/db小鼠中,ZLN005可减少RER,表明转换为脂肪酸利用.ZLN005可显著降低空腹血糖和随机血糖水平.另外,ZLN005可提高葡萄糖清除率和丙酮酸耐受,降低胰岛素抵抗[1].
参考文献：
[1]. Zhang LN, Zhou HY, Fu YY, et al. Novel Small-Molecule PGC-1a Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice. Diabetes, 2013, 62(4): 1297-1307.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 250.34 |
| Cas No. | 49671-76-3 |
| Formula | C17H18N2 |
| Solubility | ≥23.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 2-(4-tert-butylphenyl)-1H-benzimidazole |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
