Zearalanone
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ¥2370.00 | 10-15工作日发货 |
特色产品
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
产品描述
Zearalanone (ZAN) is an estrogen receptor agonist and also an androgen receptor antagonist [1].
Zearalenone (ZEN), a β-resorcyclic acid lactone (RAL), is a non-steroidal estrogenic mycotoxin biosynthesized by several Fusarium species. Zearalenone (ZEN) is the well-known mycotoxin present in numerous agricultural products [1][2][3][4]. In the human endometrial Ishikawa cell line, zearalenone (ZEN) exhibited strong oestrogenicity [4].When incubated Fusarium semitectum on sorghum, the ratio of ZAN to ZEN remained constant after 5 days, suggesting that ZAN might not be suitable for use as an internal standard [5].
Zearalanone, a major phase I metabolite of zearalenone (ZEN), is an estrogen receptor agonist and also an androgen receptor antagonist. In MCF-7 cells, Zearalanone strongly induced cell proliferation with EC50 value of 1.21 nM and showed significant estrogenic activity. Zearalanone behaved as full hERα agonist. In PALM cells, Zearalanone acted as a hAR antagonist that strongly inhibited the luciferase activity induced by 0.3 nM of R1881, the synthetic androgen [1].
References:
[1]. Molina-Molina JM, Real M, Jimenez-Diaz I, et al. Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. Food Chem Toxicol.2014 Dec;74:233-9.
[2]. Baldwin RS, Williams RD, Terry MK. Zeranol: a review of the metabolism, toxicology, and analytical methods for detection of tissue residues. Regul Toxicol Pharmacol. 1983 Mar;3(1):9-25.
[3]. Migdalof BH, Dugger HA, Heider JG, et al. Biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. Xenobiotica. 1983 Apr;13(4):209-21.
[4]. Le Guevel R, Pakdel F. Assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods. Hum Reprod. 2001 May;16(5):1030-6.
[5]. Aoyama K, Ishikuro E, Noriduki H, et al. Formation Ratios of Zearalanone, Zearalenols, and Zearalanols versus Zearalenone during Incubation of Fusarium semitectum on Sorghum and Ratios in Naturally Contaminated Sorghum. Shokuhin Eiseigaku Zasshi. 2015;56(6):247-51.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 5975-78-0 |
| 分子式 | C18H24O5 |
| 分子量 | 320.4 |
| 化学名称 | (3S)-3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione |
| 溶解度 | Soluble in DMSO |
| SMILES | C[C@@H](CCCC(CCCCCc1cc(O)cc(O)c11)=O)OC1=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献,APExBIO并未验证,仅供参考)
IC50和靶点
| 生物活性描述 | 玉米赤霉烯酮是一种非甾体雌激素霉菌毒素,由定植于多种谷物的镰刀菌产生。玉米赤霉烯酮的急性毒性和致癌性较低。由于其对雌激素受体的激动作用,玉米赤霉烯酮在一些动物物种中表现出明显的雌激素和同化特性,从而对生殖系统产生严重影响。 |



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