YYA-021
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
YYA-021是小分子CD4类似物,能抑制HIV侵入[1].
CD4是一种细胞表面蛋白.1型人免疫缺陷病毒(HIV-1)通过病毒包膜糖蛋白gp120与细胞表面CD4的相互作用,进而侵入靶细胞.CD4类似物抑制gp120与CD4的相互作用,由此抑制HIV侵入[1].
YYA-021是小分子CD4类似物,能抑制HIV侵入.YYA-021完全抑制gp120-CD4相互作用[1].在感染猿猴人类免疫缺陷病毒分离株MNA(SHIV MNA)或HIV-1 MNA假病毒的TZM-bl细胞中,YYA-021抑制SHIV MNA和HIV-1包膜糖蛋白侵入.KD-247 (anti-V3 loop mAb,50 μg)中和50% 的HIV-1 MNA.然而,20 μM YYA-021存在的情况下,KD-247 (<0.05 μg)中和50%的HIV-1 MNA,表明YYA-021和KD-247具有协同中和作用.YYA-021存在的情况下,SHIV MNA对IgG更加敏感[2].
在Jcl:SD大鼠中,YYA-021.HCl的最大耐受剂量为2.5 mg.尾静脉注射的YYA-021基于其疏水性,表现出广泛的组织分布.在恒河猴中,YYA-021.HCl的最大耐受剂量为35.3 mg [1].
参考文献：
[1]. Hashimoto C, Narumi T, Otsuki H, et al. A CD4 mimic as an HIV entry inhibitor: pharmacokinetics. Bioorg Med Chem, 2013, 21(24): 7884-7889.
[2]. Otsuki H, Hishiki T, Miura T, et al. Generation of a replication-competent simian-human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule CD4 mimic. J Gen Virol, 2013, 94(Pt 12): 2710-2716.
| Storage | Store at -20°C |
| M.Wt | 317.43 |
| Cas No. | 144217-65-2 |
| Formula | C18 H27 N3 O2 |
| Solubility | Limited solubility |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(C=C1)NC(=O)C(=O)NC2CC(NC(C2)(C)C)(C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | YYA-021是竞争性gp120-CD4相互作用抑制剂. | |||||
| 靶点 | gp120-CD4 interaction | |||||
| IC50 | ||||||
化学结构
