WAY 207024 dihydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
WAY 207024 dihydrochloride是一种有效的促性腺激素释放激素受体（GnRH-R）拮抗剂，作用于人和大鼠的GnRH受体，IC50值分别为12和71 nM[1]。
GnRH-R是G-蛋白偶联受体（GPCR）家族的成员，通过结合促性腺激素释放激素而被激活，引起垂体前叶释放黄体生成素（LH）和卵泡刺激素（FSH），它们反过来刺激性激素的合成和释放进入全身循环[1]。
WAY 207024 dihydrochloride具有中度的膜渗透性和大鼠肝微粒体稳定性[1]。
在阉割大鼠中，WAY 207024 dihydrochloride口服给药后吸收良好，有74％的生物利用度。WAY 207024 dihydrochloride（30 mg/kg，口服灌胃）在给药后的1小时开始减少血清LH的水平，而在24小时后回复到对照组水平[1]。
参考文献：
[1]. Pelletier JC, Chengalvala MV, Cottom JE, et al. Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J Med Chem, 2009, 52(7): 2148-2152.
| Physical Appearance | Off-white solid |
| Storage | Desiccate at RT |
| M.Wt | 549.54 |
| Cas No. | 872002-73-8 |
| Formula | C30H32N6·2HCl |
| Solubility | <46.71mg/ml in DMSO |
| Chemical Name | 6-((4-(2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)quinoxaline dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C1=CC=C(C2=NC3=C(N2)C=CC=C3N4CCN(CC5=CC6=C(N=CC=N6)C=C5)CC4)C=C1)C.Cl.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
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