Vitamin C

Vitamin C, a water-soluble vitamin, typically functions in the prevention and treatment of the common cold, hypersensitivity and viral infection. It has also been used as an auxiliary treatment for patients with cancer [1].

In CT26 murine colon cancer cells, 100 and 200 μg/ml Vitamin C significantly inhibited tumor cell proliferation. When concentrations of Vitamin C exceeded 200 µg/ml, tumor cells underwent apparent apoptosis. At concentrations of 200, 500 and 1000 µg/ml, Vitamin C markedly induced tumor cell apoptosis, in a dose-dependent manner. In addition, synergistic inhibitory effects of vitamin C (200 µg/ml) and Cisplatin (1 mg/ml) against CT26 tumor cells were observed [1].

In CT26 tumor-bearing BALB/c mice, tumor volume substantially decreased in the high-dose group (2, 4 and 6 mg during 8 ~ 11, 14 ~ 17 and 20 ~ 23 d after inoculation, respectively). Significant diminution of 4T1 tumor growth could also be observed following low- (1, 2, 3 and 4 mg during 8 ~ 11, 14 ~ 17, 20 ~ 23 and 26 ~ 29 d after inoculation, respectively) and high-dose (2, 4, 6 and 8 mg during 8 ~ 11, 14 ~ 17, 20 ~ 23 and 26 ~ 29 d after inoculation, respectively) Vitamin C treatment [1].

Reference:

[1]. Wang G, Yin T, Wang Y. In vitro and in vivo assessment of high-dose vitamin C against murine tumors. Experimental and Therapeutic Medicine, 2016, 12(5): 3058-3062.