Tulathromycin A

泰拉霉素A(Tulathromycin A)是大环内酯类抗生素[1].抗生素是一种用于治疗和预防细菌感染的抗菌剂.

将两只高致病菌株牛分枝杆菌孵育进145只小牛中.4天后,在患有临床牛呼吸道疾病(BRD)的小牛皮下注射泰拉霉素或生理盐水(2.5 mg/kg).在泰拉霉素用药的小牛体内, 牛呼吸道疾病相关的戒断\直肠温度峰值及肺病变记分显著降低[2].在治疗有可能发展成牛呼吸道疾病的高风险牛时,泰拉霉素(78%)和替米考星(tilmicosin )(65%) 的治愈率明显高于生理盐水(23.8%).泰拉霉素(78.4%)的治愈率也明显高于替米考星(64.9%) [3].

泰拉霉素抑制90%的溶血性曼氏杆菌(巴斯德氏菌) (MIC90)生长的最低浓度为2 μg/ml,对多杀性巴氏杆菌(牛)的最低浓度为1 μg/ml,对多杀性巴氏杆菌(猪)的最低浓度为2 μg/ml,对睡眠嗜组织菌的最低浓度为0.5-4 μg/ml,对胸膜肺炎放线杆菌的最低浓度为4-16 μg/ml[1].已批准泰拉霉素可用于治疗和预防猪与牛的呼吸道疾病[1].

参考文献：
[1].  Godinho KS, et al. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology.Vet Ther, 2005, 6(2): 113-121.
[2].  Godinho KS, et al. Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves.Vet Ther, 2005, 6(2): 96-112.
[3].  Kilgore WR, Spensley MS, Sun F, et al. Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves.Vet Ther, 2005, 6(2): 143-153.