Triacsin C
酰基辅酶A合成酶抑制剂
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 500ug | ￥4940.00 | 10-15工作日发货 | |
| 1mg | ￥8880.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Triacsin C is a potent inhibitor of long chain acyl-CoA synthetase, with an IC50 value of 6.3 μM in Raji cell membrane fraction. Long chain acyl-CoA synthetase is essential for catalyzing the conversion of free fatty acids to acyl-CoAs. Inhibition of acyl-CoA synthetase has been shown to interfere lipid synthesis as well as cell proliferation in Raji lymphoma cells. Triacsin C also induces apoptosis in many cancer cell lines, such as human lung cancer cells. In addition, Triacsin C has been found to be highly effective against rotavirus replication.
References:
1. Tomoda H, Igarashi K, Cyong JC, et al. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Journal of Biological Chemistry, 1991, 266(7): 4214-4219.
2. Mashima T, Oh-hara T, Sato S, et al. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. Journal of the National Cancer Institute, 2005, 97(10): 765-777.
3. Kim Y, George D, Prior AM, et al. Novel triacsin C analogs as potential antivirals against rotavirus infections. European Journal of Medicinal Chemistry, 2012, 50: 311-318.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 76896-80-5 |
| 分子式 | C11H17N3O |
| 分子量 | 207.27 |
| 化学名称 | (E)-N'-((2E,4E,7E)-undeca-2,4,7-trien-1-ylidene)nitrous hydrazide |
| 溶解度 | ≥5 mg/mL in DMSO; ≥5 mg/mL in EtOH |
| SMILES | CCC/C=C/C/C=C/C=C/C=N/NN=O |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | Triacsin C 来自金黄色链霉菌（Streptomyces aureofaciens）；是一种天然的酰基-CoA 合成酶（ACSL）细胞内长链抑制剂。 |
沪公网安备 31011002003500