Suramin hexasodium salt
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥650.00 | 现货 | |
| 10mg | ￥950.00 | 现货 | |
| 25mg | ￥1650.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Suramin hexasodium salt, as a polysulfonated naphthylurea, is a potent competitive inhibitor of DNA topoisomerase II, with an IC50 of 5 μM.
DNA topoisomerase II cuts both strands of the DNA helix simultaneously to manage DNA tangles and supercoils. Once cut, the ends of the DNA are separated and another DNA duplex passed through the break. then the cut DNA is religated.
Suramin can inhibit cell proliferation and DNA synthesis in HeLa cells culture. It abolishes the replication of SV40 DNA completely with 40 μM concentration. DNA polymerase α is more sensitive to concentrations of suramin than DNA polymerase δ with the IC50 of 8 µM and 36 µM respectively. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins and RecA-catalysed proteolytic cleavage of the LexA repressor. The inhibition mechanism of suramin involves its ability to disassemble RecA–single-stranded DNA filaments.
In the animal assay, compared to control rats, treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen.
References:
[1].Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.
[2].Nautiyal A, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43.
[3].Bojanowski K, et al. Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcomacells. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3025-9.
[4].Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073.
产品性质
| 物理外观 | A solid |
| CAS号 | 129-46-4 |
| 分子式 | C51H34N6Na6O23S6 |
| 分子量 | 1429.15 |
| 小分子别名 | Suramin sodium salt |
| 化学名称 | sodium 8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonate) |
| 溶解度 | ≥71.45 mg/mL in H2O; insoluble in EtOH; ≥21 mg/mL in DMSO |
| SMILES | [O-]S(=O)(C1=C(C(NC(C2=CC=C(C)C(NC(C3=CC=CC(NC(NC4=CC(C(NC5=CC(C(NC(C(C6=CC(S([O-])(=O)=O)=C7)=C7S([O-])(=O)=O)=CC=C6S([O-])(=O)=O)=O)=CC=C5C)=O)=CC=C4)=O)=C3)=O)=C2)=O)=CC=C8S([O-])(=O)=O)C8=CC(S([O-])(=O)=O)=C1)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] |
| 存储条件 | 4℃ 密封，干燥，避光 |
| 运输条件 | 常温 |
| 注意事项 | 产品具有吸湿性 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 苏拉明钠盐（苏拉明六钠盐）是一种可逆的竞争性蛋白酪氨酸磷酸酶（PTPases）抑制剂。苏拉明钠盐是一种强效的 sirtuins 抑制剂：SirT1（IC50=297 nM）、SirT2（IC50=1.15 μM）和 SirT5（IC50=22 μM）。苏拉明钠盐是逆转录酶（DNA 拓扑异构酶 II：IC50=5 μM）的竞争性抑制剂。苏拉明钠盐是一种强效的 SARS-CoV-2 RNA 依赖性 RNA 聚合酶（RdRp）抑制剂。苏拉明钠盐能有效抑制 IP5K，是一种抗寄生虫、抗肿瘤和抗血管生成剂。 |
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