Suramin hexasodium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Suramin hexasodium salt, as a polysulfonated naphthylurea, is a potent competitive inhibitor of DNA topoisomerase II, with an IC50 of 5 μM.
DNA topoisomerase II cuts both strands of the DNA helix simultaneously to manage DNA tangles and supercoils. Once cut, the ends of the DNA are separated and another DNA duplex passed through the break. then the cut DNA is religated.
Suramin can inhibit cell proliferation and DNA synthesis in HeLa cells culture. It abolishes the replication of SV40 DNA completely with 40 μM concentration. DNA polymerase α is more sensitive to concentrations of suramin than DNA polymerase δ with the IC50 of 8 µM and 36 µM respectively. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins and RecA-catalysed proteolytic cleavage of the LexA repressor. The inhibition mechanism of suramin involves its ability to disassemble RecA–single-stranded DNA filaments.
In the animal assay, compared to control rats, treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen.
References:
[1].Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7.
[2].Nautiyal A, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43.
[3].Bojanowski K, et al. Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcomacells. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3025-9.
[4].Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 1429.15 |
| Cas No. | 129-46-4 |
| Formula | C51H34N6Na6O23S6 |
| Solubility | ≥71.45 mg/mL in H2O; insoluble in EtOH; ≥21 mg/mL in DMSO |
| Chemical Name | sodium 8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonate) |
| SDF | Download SDF |
| Canonical SMILES | [O-]S(=O)(C1=C(C(NC(C2=CC=C(C)C(NC(C3=CC=CC(NC(NC4=CC(C(NC5=CC(C(NC(C(C6=CC(S([O-])(=O)=O)=C7)=C7S([O-])(=O)=O)=CC=C6S([O-])(=O)=O)=O)=CC=C5C)=O)=CC=C4)=O)=C3)=O)=C2)=O)=CC=C8S([O-])(=O)=O)C8=CC(S([O-])(=O)=O)=C1)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
