STF-118804
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
STF-118804是NAMPT的抑制剂[1]
烟酰胺磷酸转移酶(NAMPT)是烟酰胺腺嘌呤二核苷酸(NAD+)生物合成的限速酶,NAD+是许多生化和生物学过程中的重要辅因子.并且,NAMPT是一种抑制嗜中性粒细胞凋亡和促进B细胞成熟的细胞因子[1].
STF-118804是NAMPT的抑制剂.在B-ALL细胞系中,STF-118804可高效降低细胞活力.在小儿急性淋巴细胞白血病(ALL)分离的白血病样品中,STF-118804降低细胞活力的IC50值为3.1-32.3 nM.在MV411细胞中,STF-118804可诱发细胞凋亡而不引起细胞周期停滞.并且,STF-118804在结肠和前列腺细胞系中非常有效.STF-118804(10 μM)可抑制由烟酰胺合成NAD+.在过表达NAMPT的293T细胞中,STF-118804可降低细胞活力,IC50值为106 nM.另外,STF-118804对过表达H191R或G217R突变体的细胞没有效果[1].
在ALL原位异种移植小鼠模型中,STF-118804可提高存活率,并能抑制肿瘤生长.另外,STF-118804可有效减少白血病干细胞[1].
参考文献：
[1]. Matheny CJ, Wei MC, Bassik MC, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol, 2013, 20(11): 1352-1363.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 461.53 |
| Cas No. | 894187-61-2 |
| Formula | C25H23N3O4S |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥19.1 mg/mL in DMSO |
| Chemical Name | 4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)CC2=C(OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
