Stavudine (d4T)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB-271046是一种有效的具有口服活性的5-HT6受体选择性拮抗剂(在体外HeLa细胞中pKi = 8.9).
5-HT受体是一种神经系统中的5-羟色胺(血清素)的G蛋白偶联受体.该物质是多种生物碱和神经活性物质的受体.
在原生大脑组织中,SB-271046对人类重组5-HT6受体和5-HT6受体具有高亲和性.与受试的所有其他5-HT受体亚型相比,SB-271046对5-HT6受体具有200倍的选择性.[1]
在大鼠MEST(最大电癫痫发作阈值)试验中,广泛剂量的SB-271046可提高惊厥阈值,最小有效剂量为40.1 mg·kg-1 p.o.,最大效果在给药后4 h达到.[1]在测定大鼠行为获得和保留的Morris水迷宫中,galanthamine和SB-271046结合疗法可逆转莨菪碱或MK-801诱发的学习障碍.[2]
参考文献：
1. Routledge C, Bromidge SM, Moss SF et al. Characterization of SB-271046: a potent, selective and orally active 5-HT (6) receptor antagonist. Br J Pharmacol. 2000 Aug; 130(7):1606-12.
2. Marcos B, Chuang TT, Gil-Bea FJ, Ramirez MJ. Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br J Pharmacol. 2008 Oct;155(3):434-40.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 224.21 |
| Cas No. | 3056-17-5 |
| Formula | C10H12N2O4 |
| Solubility | ≥51.3 mg/mL in H2O; ≥8.4 mg/mL in DMSO; ≥9.72 mg/mL in EtOH with ultrasonic |
| Chemical Name | 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
