SR33805
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SR33805 是一种有效的 Ca2+ 通道阻滞剂。 在去极化条件下（即保持电位为 -40 mV），SR33805 的 EC50 为 4.1 nM，在极化条件下（即保持电位为 -80 mV），其 EC50 为 33 nM。 在体外，SR33805 以剂量依赖性方式抑制了生长因子诱导的 SMC 增殖 (0.20<IC(50)<0.46 μM)。 在体内，SR33805 降低了横截面积的内膜/中膜比例（减少了 60%，P < 0.05），而不影响新生内膜 SMC 密度。 此外，SR33805 (10 µM) 对于终末期心力衰竭的大鼠中分离的心肌细胞中的兴奋-收缩偶联，也产生了影响。 SR33805 的急性治疗恢复了心肌梗死改变的细胞缩短而不影响 Ca2+ 的瞬时幅度，表明心肌梗死肌细胞中肌丝 Ca2+ 敏感性的增加。单次腹膜内注射SR33805（20mg/kg）可改善心肌梗死心脏的收缩末期应变和缩短分数。
1. Romey G, et, al. Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. Eur J Pharmacol. 1994 Sep 22; 263(1-2): 101-5.
2. Mou YA, et, al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011 Aug 1; 91(3): 412-9.
3. Hainaud P, et, al. The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery. Atherosclerosis. 2001 Feb 1; 154(2): 301-8.
| Storage | Store at -20°C |
| M.Wt | 564.74 |
| Cas No. | 121345-64-0 |
| Formula | C32H40N2O5S |
| Solubility | ≥52.7 mg/mL in DMSO |
| Chemical Name | N-(3,4-dimethoxyphenethyl)-3-(4-((2-isopropyl-1-methyl-1H-indol-3-yl)sulfonyl)phenoxy)-N-methylpropan-1-amine |
| SDF | Download S |
| Canonical SMILES | O=S(C1=CC=C(OCCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1)(C3=C(C(C)C)N(C)C4=C3C=CC=C4)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
