SNC 80

SNC 80 is a highly selective and potent nonpeptide agonist of the δ-opioid receptor, with an IC50 value of 2.73 nM. The δ-opioid receptor, most heavily expressed in the basal ganglia and neocortical regions of the brain in human, participates not solely in the control of pain but also of mood disorders such as anxiety and depression. Selective δ-opioid receptor agonists may serve as potential therapeutic agents for chronic pain with ancillary anxiolytic- and antidepressant-like effects. Moreover, compared to μ-opioid receptor agonists, molecules acting on δ-opioid receptors typically show reduced adverse effects.

References:

1. Calderon SN, Rothman RB, Porreca F, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. Journal of Medicinal Chemistry, 1994, 37(14): 2125-2128.

2. Quirion B, Bergeron F, Blais V, et al. The Delta-Opioid Receptor; a Target for the Treatment of Pain. Frontiers in Molecular Neuroscience, 2020, 13: 52.

3. Bilsky EJ, Calderon SN, Wang T, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. Journal of Pharmacology and Experimental Therapeutics, 1995, 273(1): 359-366.