SDZ 220-581 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SDZ 220-581 hydrochloride是有效的NMDA受体竞争性拮抗剂,其pKi值为7.7[1].
SDZ220-581是一种联苯AP7衍生物,在体内外均显效.SDZ 220-581以高亲和力结合到NMDA受体的识别位点,而不会结合NMDA受体的士的宁不敏感甘氨酸位点或MK-801位点.此外,SDZ 220-581对其它各种结合试验没有影响,如多巴胺\血清素和腺苷[1].
在体内试验中,SDZ 220-581保护小鼠免受最大电休克诱发的癫痫(MES).在大鼠MES模型中,SDZ 220-581也显效.此外,在大鼠中,SDZ 220-581可以保护大脑免受喹啉酸诱导的神经元变性.在局灶性脑缺血大鼠模型中,1.25 mg/kg SDZ 220-581显著降低脑梗塞大小[2].
参考文献：
[1] Urwyler et al . Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 1996, 35 655.
[2] Urwyler S, Campbell E, Fricker G, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiveN-Methyl-D-aspartate receptor antagonists—II. Pharmacological characterization in vivo[J]. Neuropharmacology, 1996, 35(6): 655-669.
| Storage | Store at -20°C |
| M.Wt | 406.2 |
| Cas No. | 179411-93-9 |
| Formula | C16H18Cl2NO5P |
| Solubility | Soluble in DMSO |
| Chemical Name | (S)-2-amino-3-(2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-yl)propanoic acid hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | ClC1=CC=CC=C1C2=CC(C[C@@](N)([H])C(O)=O)=CC(CP(O)(O)=O)=C2.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
