Scriptaid是通过高通量转录筛选鉴定到的，是一种新型的组蛋白去乙酰化酶（HDAC）抑制剂，对I类HDACs具有特异性（作用于HDAC1/HDAC3和HDAC8，IC50值分别为0.6 μM和1 μM）。Scriptaid与其它几个包含羟肟酸的HDAC抑制剂（如TSA和nullscript）具有相似的化学结构，由一个羟肟酸基、一个脂肪链和另一端的芳香帽组成。Scriptaid具有治疗胶质母细胞瘤（GBM）的潜力，能够诱导胶质瘤细胞的凋亡。GBM是最具挑战性的实体瘤之一。

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