(S)-(-)-Propranolol hydrochloride
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 1mL(10 mM in H2O) | ￥454.00 | 现货 | |
| 100mg | ￥409.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
(S)-(-)-Propranolol hydrochloride is a more active enantiomer of propranolol, acting as a β-adrenoceptor antagonist with log Kd values being -8.16, -9.08 and -6.93 for human β1-, β2- and β3-adrenoceptors stably expressed in Chinese hamster ovary cells, respectively. β-Adrenoceptor antagonists are one of the most commonly used classes of drugs in cardiovascular medicine (hypertension, ischemic heart disease and heart failure) as well as in the management of anxiety, migraine and glaucoma. In addition, (S)-(-)-propranolol hydrochloride is also a non-specific serotonin receptor antagonist, capable of inhibiting the behavioral responses to increased brain 5-hydroxytryptamine (5-HT).
References:
1. Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British Journal of Pharmacology, 2005, 144(3): 317-322.
2. Costain DW, Green AR. beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. British Journal of Pharmacology, 1978, 64(2): 193-200.
3. Barrett AM, Cullum VA. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. British Journal of Pharmacology, 1968, 34(1): 43-55.
产品性质
| 物理外观 | A solid |
| CAS号 | 4199-10-4 |
| 分子式 | C16H21NO2·HCl |
| 分子量 | 295.81 |
| 化学名称 | (S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride |
| 溶解度 | ≥15.65 mg/mL in H2O; ≥2.9 mg/mL in EtOH with gentle warming and ultrasonic; ≥57.5 mg/mL in DMSO |
| SMILES | CC(C)NC[C@@H](COc1cccc2c1cccc2)O.Cl |
| 存储条件 | 室温 |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | (S)-(-)-盐酸普萘洛尔是一种 β 肾上腺素能受体拮抗剂，对 β1、β2 和 β3 的对数 Kd 值分别为 -8.16、-9.08 和 -6.93。(S)-(-)-盐酸普萘洛尔是普萘洛尔的活性对映体，可用于研究高血压、嗜铬细胞瘤、心肌梗塞、心律失常、心绞痛和肥厚型心肌病。 |
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