Catalog No. A8173

Romidepsin (FK228, depsipeptide)

Name: Romidepsin (FK228, depsipeptide), 罗米地辛, Romidepsin, 128517-07-7
Brand: APExBIO
SKU: A8173
Price: 2636 CNY
Availability: InStock

（别名：Romidepsin; 罗米地辛）

选择性的HDAC1/HDAC2抑制剂

规格	价格	货期
1mL(10 mM in DMSO)	￥2636.00	现货
1mg	￥909.00	现货
5mg	￥2545.00	现货

CAS号：128517-07-7纯度：99.14%

仅用于科研，不用于诊疗。未经明确授权不得转售。

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特色产品

Annexin V-FITC/PI Apoptosis Kit

用于双染检测细胞凋亡和坏死

- 在10-20分钟内完成染色
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞

Phos binding reagent (Phosbind) acrylamide

分离和检测磷酸化/非磷酸化蛋白

- 新型的磷酸盐结合标签和功能分子
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白

Cell Counting Kit-8 (CCK-8)

用于细胞增殖和细胞毒性试验

- 比MTT，MTS或WST-1更敏感
- 对细胞无毒性
- 步骤更简单，无需有机溶剂

Cy5 TSA Fluorescence System Kit

Cy5荧光标记的酪胺信号放大系统

- 检测ICC/IHC/ISH中的低丰度靶点
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率

EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)

用于观察mRNA运送，定位，翻译

- 具有Cap1结构的荧光素酶mRNA
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰

HotStart™ 2X Green qPCR Master Mix

用于荧光定量目标DNA或cDNA

- 通过热启动机制优化扩增特异性
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单

HyperScribe™ T7 High Yield Cy5 RNA Labeling Kit Plus

高效的Cy5修饰RNA转录试剂盒

- 适合原位/Northernblot杂交实验
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量

产品描述产品性质产品应用生物相关数据质量控制操作说明产品引用文献摩尔浓度计算器

产品描述

Romidepsin（FK228，depsipeptide）是一种有效的和选择性的HDACs抑制剂。HDACs可以调控沉默性肿瘤抑制基因的表达。HDACs可以从组蛋白N端的赖氨酸残基上去除乙酰基，使染色质维持一个更加开放的转录活性状态。Romidepsin是第一个体现抗肿瘤活性的HDAC抑制剂，最初是从日本土壤样品中的棒状革兰氏阴性菌Chromobacterium violaceum中分离出来的。Romidepsin对HDAC1和HDAC2（I类）的抑制活性比HDAC4和HDAC6（II类）更强。除了抑制HDACs，romidepsin还可以诱导细胞周期停滞、细胞分化、细胞凋亡和成人恶性肿瘤中基因表达的变化。

参考文献：
Karen M VanderMolen, William McCulloch, Cedric J Pearce and Nicholas H Oberlies. Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma. The Journal of Antibiotics 2011: 64, 525-531
Jyoti Panicker, Zhijie Li, Christine McMahon, Caroline Sizer, Kenneth Steadman, Richard Piekarz, Susan E. Bates and Carol J. Thiele. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells. Cell Cycle 2010 9:9, 1830-1838

产品性质

物理外观	A solid
CAS号	128517-07-7
分子式	C₂₄H₃₆N₄O₆S₂
分子量	540.7
小分子别名	Romidepsin
化学名称	(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
溶解度	≥27.04 mg/mL in DMSO; insoluble in H2O; ≥35.27 mg/mL in EtOH with ultrasonic
SMILES	CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
存储条件	-20°C
运输条件	蓝冰

产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)

IC50和靶点

生物活性描述	Romidepsin (FK228；depsipeptide)是一种有效的和选择性的I类HDACs抑制剂；在无细胞试验中作用于HDAC1、HDAC2、HDAC4和HDAC6；IC50值分别为36、47、510和14000 nM。
靶点	HDAC1	HDAC2
生物活性数据	36 nM	47 nM

生物相关数据

质量控制

请选择批次查看:

纯度 = 99.14%

COA (Certificate Of Analysis)HPLC MS (Mass Spectrometry)MSDS (Material Safety Data Sheet)

操作说明

Datasheet 小分子化合物通用使用指南

APExBIO 顾客使用本产品发表的 14 篇科研文献

1. Hongyu Zhang, Baojin Zhou, et al. "Multidimensional Proteomics Reveals the Pro-apoptotic Mechanism of Platycodin D: Targeting RFC4 to Regulate the Notch Signaling Axis in Non-Small Cell Lung Cancer." Mol Cell Proteomics. 2026 May 15:101587. PMID: 42142580

2. Linmao Sun, Yufeng Liu, et al. "Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors." Nat Commun. 2024 Jun 18;15(1):5209. PMID: 38890388

3. Amy E Neely, Laura A Blumensaadt, et al. "NUP98 and RAE1 sustain progenitor function through HDAC-dependent chromatin targeting to escape from nucleolar localization." Commun Biol. 2023 Jun 23;6(1):664. PMID: 37353594

4. Rie Hagiwara, Kazunori Kageyama, et al. "Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells." Peptides. 2020 Nov 9;136:170441. PMID: 33181265

5. Kulpa DA, Talla A, et al. "Differentiation to an effector memory phenotype potentiates HIV-l latency reversal in CD4+ T cells." J Virol. 2019 Oct 2. pii: JVI.00969-19. PMID: 31578289

6. Tang Y, Yu W. "SIRT1 and p300/CBP regulate the reversible acetylation of serine-threonine kinase NDR2." Biochem Biophys Res Commun. 2019 Aug 16. pii: S0006-291X(19)31586-4. PMID: 31427083

7. Tiffany C. Chang, Margarite D. Matossian, et al. "Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor." bioRxiv. 2019 November 29

8. Kim SR, Lewis JM, et al. "BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition." Oncotarget.2018 Jun 26;9(49):29193-29207. PMID: 30018745

9. Nakano Y, Kelly MC, et al. "Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness." Cell. 2018 Jul 26;174(3):536-548.e21. PMID: 29961578

10. Ho CF, Bon CP, et al. "Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells." Neurochem Res. 2017 Dec 12. PMID: 29235036

11. Tarasenko N, Chekroun-Setti H, et al. "COMPARISON OF THE ANTICANCER PROPERTIES OF A NOVEL VALPROIC ACID PRODRUG TO LEADING HISTONE DEACETYLASE INHIBITORS." J Cell Biochem. 2017 Nov 14. PMID: 29135083

12. Bagnall NH, Hines BM, et al. "Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina." Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):51-60. PMID: 28110187

13. a RC, Popova EY, et al. "Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina." J Biol Chem. 2017 Feb 10;292(6):2422-2440. PMID: 28028172

14. Li QQ, Hao JJ, et al. "Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach." Int J Oncol. 2016 Jun;48(6):2591-607. PMID: 27082124