Rilmenidine Phosphate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rilmenidine phosphate是Rilmenidine的水溶形式.该物质是以咪唑啉受体为靶点的抗高血压药.[1]
咪唑啉受体是一类可乐定\咪唑克生和其他咪唑啉药物的非肾上腺素能的高亲和性结合位点.[2]咪唑啉受体有三类.I-1介导对低血压的交感抑制作用;I-2是单胺氧化酶的别构结合位点;I-3可控制胰腺细胞的胰岛素分泌.[3]
在以0.5 mM十八烯酸处理6小时并用1 μM的Rilmenidine处理30分钟的Hep G2细胞中,十八烯酸诱导的脂质积累减少.[4]Rilmenidine对咪唑啉I-1受体的刺激可活化P38,诱导FXR表达.[4]
饲喂HFD(高脂饮食)的小鼠在使用Rilmenidien后,通过激活咪唑啉I-1受体改善了脂肪肝.[4]咪唑啉受体参与血压的延髓调控,并可影响外周积累.[1]在高血压病人中,Rilmenidine可以剂量依赖的方式降低血压.与安慰剂相比,Rilmenidine可显著降低血压.此外,Rilmenidine与其他抗高血压药物相比,发生不利效应的可能性显著降低.[1]
参考文献：
[1] Laurent S, Safar M. Rilmenidine: a novel approach to first-line treatment of hypertension. Am J Hypertens. 1992 Apr;5(4 Pt 2):99S-105S.
[2] Regunathan S, Reis DJ. Imidazoline receptors and their endogenous ligands.Annu Rev Pharmacol Toxicol. 1996;36:511-44.
[3] Head GA, Mayorov DN. Imidazoline receptors, novel agents and therapeutic potential. Cardiovasc Hematol Agents Med Chem. 2006 Jan;4(1):17-32.
[4] Yang PS, Wu HT, Chung HH, Chen CT, Chi CW, Yeh CH, Cheng JT. Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan;385(1):51-6.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 278.24 |
| Cas No. | 85409-38-7 |
| Formula | C10H19N2O5P |
| Solubility | insoluble in EtOH; ≥30.15 mg/mL in H2O; ≥5.68 mg/mL in DMSO |
| Chemical Name | N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine phosphate |
| SDF | Download SDF |
| Canonical SMILES | OP(O)(O)=O.C1(NC(C2CC2)C3CC3)=NCCO1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
