Rhosin hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rhosin hydrochloride是一种有效和特异性的RhoA subfamily Rho GTPases抑制剂（Kd = 0.4μM）。Rho family GTPases是关键的细胞内信号分子，可调节细胞骨架组织、基因表达、细胞周期进程、细胞运动和其他细胞过程。Rhosin在体外和细胞内，能特异性抑制RhoA的GEF激活，并能有效抑制乳腺癌细胞的增殖和侵袭，还能诱导PC12细胞中的神经轴突生长。在体内，Rhosin被用来抑制慢性社交挫败应激后的RhoA活性。对D1 MSNs （中型多棘神经元）进行全细胞电生理记录，以评估Rhosin治疗对应激小鼠的突触和内在后果, 数据表明，抑制RhoA可防止D1-MSNs的过度兴奋性和社交挫败应激导致的D1-MSN兴奋性输入减少。Rhosin能增强与D1-MSN兴奋性相关的脊柱密度，而不影响整体树突分支。
1. Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710.
2. Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.
3. Francis TC, et al. The Selective RhoA Inhibitor Rhosin Promotes Stress Resiliency Through Enhancing D1-Medium Spiny Neuron Plasticity and Reducing Hyperexcitability. Biol Psychiatry. 2019;85(12):1001-1010.
| Storage | Store at -20°C |
| M.Wt | 394.86 |
| Cas No. | 1281870-42-5 |
| Formula | C20H19ClN6O |
| Solubility | ≥39.7 mg/mL in DMSO |
| Chemical Name | (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | O=C([C@@H](CC1=CNC2=C1C=CC=C2)N)N/N=C/C3=CC=C4N=CC=NC4=C3.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
