Oleic Acid

Oleic acid is a monounsaturated fatty acid naturally found in many animal and vegetable fats and oils.

In 786-O cells, treatment with oleic acid upregulated ILK. In breast cancer, oleic acid activates G protein-coupled receptors and phosphorylates ERK1/2, inducing cancer cell proliferation[1].

Oleic acid inhibits Na/K-ATPase activity in the lungs and lungs during injury. Oleic acid (10 μM) induces pulmonary edema, inflammation and cell influx, liposome formation, and the production of leukotriene B4 (LTB4) and PGE2[2].

Reference:

[1]. Harvey K A, Walker C L, Xu Z, et al. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. Journal of Lipid Research, 2010, 51(12): 3470-3480.

[2]. Goncalvesdealbuquerque C F, Burth P, Silva A R, et al. Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production. Journal of Inflammation, 2013, 10(1): 34-34.