NADPH (sodium salt)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 25mg | ￥275.00 | 现货 | |
| 50mg | ￥473.00 | 现货 | |
| 100mg | ￥757.00 | 现货 | |
| 250mg | ￥1589.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
NADPH is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions. In plants, NADPH is produced by ferredoxin-NADP+ reductase in the last step of the electron chain during photosynthesis. In animals is it predominantly produced by the pentose phosphate pathway, but is also generated by key mitochondrial enzymes. NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species[1-3].
References:
[1]. Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. febs journal, 2008, 275(13): 3249-3277.
[2]. Sutherland M W, Nelson J, Harrison G, et al. Effects of t-butyl hydroperoxide on NADPH, glutathione, and the respiratory burst of rat alveolar macrophages. Archives of Biochemistry and Biophysics, 1986, 243(2): 325-331.
[3]. Nauseef W M. Biological Roles for the NOX Family NADPH Oxidases. Journal of Biological Chemistry, 2008, 283(25): 16961-16965.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 2646-71-1 |
| 分子式 | C21H26N7Na4O17P3 |
| 分子量 | 833.35 |
| 小分子别名 | NADPH tetrasodium salt |
| 化学名称 | sodium (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((((((((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1(4H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)-4-hydroxytetrahydrofuran-3-yl phosphate |
| 溶解度 | insoluble in EtOH; insoluble in DMSO; ≥52 mg/mL in H2O |
| SMILES | O[C@H]1[C@@H](OP([O-])([O-])=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C=C(C(N)=O)CC=C5)O4)([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+] |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | NADPH 四钠盐是一种无处不在的辅酶，在许多利用脱氢酶和还原酶进行的反应中充当电子供体。它在核苷酸、蛋白质和脂肪酸的生物合成过程中作为辅助因子发挥着至关重要的作用。它对于中和因代谢活动增加而产生的活性氧（ROS）的升高水平至关重要。 |
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