Sodium Oxamate

Sodium oxamate is a competitive LDHA(actate dehydrogenase A) inhibitor, sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis. Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various tumors[1,2].

References：

[1]. Anna Z K, De S M M L, Antonio S, et al. Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells. PLOS ONE, 2015, 10(3): e0119857.

[2]. Cui J, Shi M, Xie D, et al. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clinical Cancer Research, 2014, 20(10): 2595-2606.