Trolox
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 250mg | ￥295.00 | 现货 | |
| 500mg | ￥449.00 | 现货 | |
| 1g | ￥650.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Trolox is a cell-permeable, derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays[1,2].
Trolox can prevent thymocytes apoptosis which is induced by oxidative stress.Using trolox to pre-treat or post-treat cells can reduce H2O2-induced DNA fragments to below control levels[3].
In a mouse model, after cerebral ischemia-reperfusion, Trolox (50 mg / kg) is prescribed to increase anti-apoptotic proteins and decrease pro-apoptotic proteins, thereby protecting hippocampal neurons and causing improvement in memory[4].
References:
[1]. Cos P, Hermans N, Calomme M, et al. Comparative study of eight well-known polyphenolic antioxidants. Journal of Pharmacy and Pharmacology, 2003, 55(9): 1291-1297.
[2]. Tadolini B, Juliano C, Piu L, et al. Resveratrol inhibition of lipid peroxidation. Free Radical Research, 2000, 33(1): 105-114.
[3]. Forrest V J, Kang Y H, Mcclain D E, et al. Oxidative stress-induced apoptosis prevented by Trolox. Free Radical Biology and Medicine, 1994, 16(6): 675-684.
[4]. Sarveazad A, Babahajian A, Yari A, et al. Neuroprotective Role of Trolox in Hippocampus after Ischemia Reperfusion Injury in Mouse. International Journal for Vitamin and Nutrition Research, 2017, 86(5-6): 228-234.
产品性质
| 物理外观 | Solid |
| CAS号 | 53188-07-1 |
| 分子式 | C14H18O4 |
| 分子量 | 250.29 |
| 化学名称 | 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid |
| 溶解度 | ≥25 mg/mL in DMSO; insoluble in H2O; ≥20.75 mg/mL in EtOH |
| SMILES | CC(C(C)=C1O2)=C(O)C(C)=C1CCC2(C(O)=O)C |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | Trolox 是维生素 E 的类似物，具有强大的抗氧化作用。三环氧化物还是膜损伤的强力抑制剂。 |
生物相关数据
APExBIO 顾客使用本产品发表的 6 篇科研文献
6. Tianshu Wu, Xue Liang, et al. "Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia." Particle and Fibre Toxicology volume 17, Article number: 30 (2020).11 July 2020
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