Posaconazole hydrate
泊沙康唑水合物
Catalog No.
B1225
C14ɑ去甲基化酶抑制剂
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Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.
| Storage | Store at -20°C |
| M.Wt | 718.79 |
| Cas No. | 1198769-38-8 |
| Formula | C37H44F2N8O5 |
| Solubility | Soluble in DMSO |
| Chemical Name | 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one hydrate |
| SDF | Download SDF |
| Canonical SMILES | CC[C@@](N(N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@](CO5)([H])C[C@@]5(C6=C(F)C=C(F)C=C6)CN7C=NC=N7)C=C4)CC3)C=C2)C1=O)([H])[C@](O)([H])C.O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
