Paxilline
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥2329.00 | 10-15工作日发货 | |
| 10mg | ￥3737.00 | 10-15工作日发货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa, KCa1.1) channels[1,2]. It also enhances the binding of charybdotoxin, a peptidyl neurotoxin, to BKCa channels. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (IC50 = 5 - 50 μM)[3].
References:
[1]. Sanchez M, McManus O B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology, 1996, 35(7): 963-968.
[2]. Li G, Cheung D W. Effects of paxilline on K+ channels in rat mesenteric arterial cells. European Journal of Pharmacology , 1999, 372: 103-107.
[3]. Knaus H G, McManus O B, Lee S H, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry, 1994, 33(19): 5819-5828.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 57186-25-1 |
| 分子式 | C27H33NO4 |
| 分子量 | 435.56 |
| 化学名称 | (2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one |
| 溶解度 | Soluble in DMSO |
| SMILES | CC(C)([C@H]1O[C@@H](CC[C@](C)([C@](C)([C@@H](C2)CC3)c4c2c(cccc2)c2[nH]4)[C@@]32O)C2=CC1=O)O |
| 存储条件 | -20°C干燥 |
| 运输条件 | 蓝冰 |
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