p-MPPI hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
p-MPPI hydrochloride是一种选择性的5-HT1A受体拮抗剂。 在8-OH-DPAT处理的（0.375 mg/kg，皮下注射）前30分钟，用p-MPPI（5 mg/kg，腹腔注射）进行预处理，可降低8-OH-DPAT对清醒和REM睡眠的影响。此外，p-MPPI（5和10 mg/kg，腹腔注射）降低了8-OH-DPAT对运动的影响，并部分或完全对抗了后肢外展和平躺姿势。单用p-MPPI不会产生明显的行为改变。在雄性小鼠中使用行为学版本的高架十字迷宫试验，结果表明，在较低剂量（0.5-4.5 mg/kg）下，p-MPPI 在常规（开臂回避）和行为学（风险评估）实验中，均产生显著且与剂量相关的抗焦虑作用。
1. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.
2. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
| Storage | Store at -20°C |
| M.Wt | 578.87 |
| Cas No. | 220643-77-6 |
| Formula | C25H28ClIN4O2 |
| Solubility | ≥58.3 mg/mL in DMSO |
| Chemical Name | 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)benzamide hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | O=C(N(CCN1CCN(C2=CC=CC=C2OC)CC1)C3=NC=CC=C3)C4=CC=C(I)C=C4.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
