Olmesartan medoxomil
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Olmesartan medoxomil是olmesartan的medoxomil酯，是一种新的血管紧张素II 1型受体（AT1受体）口服抑制剂，IC50值为33 nmol/L。通过口服，olmesartan medoxomil可在胃肠道中迅速吸收，转化为其活性代谢物olmesartan，其对AT1受体的抑制常数IC50为8 nmol/L。Olmesartan与medoxomil基团的酯化作用可提高其水溶性（从4.5%到28.6%）。Olmesartan medoxomil被用于高血压治疗，可通过动脉血管舒张和减少钠潴留，剂量依赖地降低血压。
参考文献：
HR Brunner. The new oral angiotensin II antagonist olmesartan medoxomil: a concise overview. Journal of Human Hypertension (2002) 16 (Suppl 2), S13-S16
Shailesh T. Prajapati, Hitesh H. Bulchandani, Dashrath M. Patel, Suresh K. Dumaniya and Chhaganbhai N. Patel. Formulation and evaluation of liquisolid compacts for olmesartan medoxomil. Journal of Drug Delivery 2013.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 558.6 |
| Cas No. | 144689-63-4 |
| Formula | C29H30N6O6 |
| Synonyms | Benicar, Benevas, Olvance |
| Solubility | ≥21.1 mg/mL in DMSO; insoluble in H2O; ≥4.6 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
