Nourseothricin (sulfate)
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 5mg | ￥475.00 | 现货 | |
| 10mg | ￥760.00 | 现货 | |
| 50mg | ￥1900.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Nourseothricin is a broad-spectrum antibiotic.
Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei.
In vitro: Nourseothricin, represents a mixture of streptothricins, mainly D and F. Although very slowly, nourseothricin was found to be able to pass the outer membrane through the porin pores. It has been also shown that nourseothricin was able to generate some channels into the outer membrane. Moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane. In addition, such strains indeed could be rendered sensitive via damaging the barrier function of the outer membrane [1].
In vivo: Animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen. Renal handling of nourseothricin was characterized on renal cortical slices under various experimental conditions. Following administration the renal tubular transport system for organic anions was not influenced by nourseothricin. There was a high degree of accumulation of nourseothricin in renal cortical slices. In contrast to PAH accumulation, there was no influence of nitrogen atmosphere, probenecid or trishydroxyaminomethane on nourseothricin accumulation. Age dependent differences in nourseothricin accumulation did not exist [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Seltmann G. Resistance of Escherichia coli to nourseothricin (streptothricin): sensitization of resistant strains by abolition of its outer membrane resistance. Zentralbl Bakteriol. 1992 Jan;276(2):143-51.
[2] Brunlich H, Hoffmann H, Bocker H. Renal handling of nourseothricin. Pharmazie. 1988 Mar;43(3):200-2.
产品性质
| 物理外观 | A crystalline solid |
| CAS号 | 96736-11-7 |
| 分子式 | C31H58N12O10·C19H34N8O8·H2SO4 |
| 分子量 | 1359.48 |
| 小分子别名 | Nourseothricin sulfate |
| 化学名称 | sulfuric acid--(2R,3R,4S,5R,6R)-5-((S)-3,6-diaminohexanamido)-4-hydroxy-6-(((3aS,7R,7aS)-7-hydroxy-4-oxo-3a,4,5,6,7,7a-hexahydro-1H-imidazo[4,5-c]pyridin-2-yl)amino)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl carbamate--(2R,3R,4S,5R,6R)-5-((S)-3-amino-6-(( |
| 溶解度 | 2.51 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| SMILES | O=C(C[C@@H](N)CCCN)N[C@H]1[C@H](NC2=N[C@@](C(NC[C@H]3O)=O)([H])[C@]3([H])N2)O[C@H](CO)[C@H](OC(N)=O)[C@H]1O.OS(=O)(O)=O.O=C(C[C@@H](N)CCCNC(C[C@@H](N)CCCNC(C[C@@H](N)CCCN)=O)=O)N[C@H]4[C@H](NC5=N[C@@](C(NC[C@H]6O)=O)([H])[C@]6([H])N5)O[C@H](CO)[C@H](OC(N) |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 硫酸诺索三嗪（Streptothricin sulfate）是一种广谱抗生素，能破坏革兰氏阴性细菌的外膜，是 Fonsecaea pedrosoi 的主要选择性标记。硫酸诺索三嗪可抑制原核细胞的蛋白质生物合成，并强烈抑制真菌等真核生物的生长，还可用作细菌、酵母、丝状真菌和植物细胞等多种生物的选择性标记。 |
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