NBQX disodium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NBQX disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors (AMPARs). The AMPAR is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as Alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. Inhibition of AMPARs with NBQX shows neuroprotective and anticonvulsant activity.
References:
1. Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. Journal of Biomolecular Screening, 2014, 19(8): 1174-1184.
2. Chen W, Li YS, Gao J, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One, 2016, 11(11): e0166672.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 380.24 |
| Cas No. | 479347-86-9 |
| Formula | C12H6N4O6SNa2 |
| Solubility | Soluble in H2O |
| Chemical Name | sodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-bis(olate) |
| SDF | Download SDF |
| Canonical SMILES | O=S(N)(C1=CC=CC2=C1C([N+]([O-])=O)=CC(N=C3[O-])=C2N=C3[O-])=O.[Na+].[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[1] | |
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Cell lines |
HIP-009 cells |
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Reaction Conditions |
1 h incubation |
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Applications |
NBQX inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 µM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX treatment. |
| Animal experiment:[2] | |
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Animal models |
Male Wistar rats intraperitoneally injected with pentylenetetrazole |
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Dosage form |
20 mg/kg Once daily by intraperitoneal injection for 3 days |
|
Applications |
NBQX was sufficient to decrease pentylenetetrazole-induced seizures through increasing the latency to seizures, decrease the duration of seizure onset, and reduce the scores for the severity of seizures. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Fukushima K, Tabata Y, Imaizumi Y, et al. Characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. Journal of Biomolecular Screening, 2014, 19(8): 1174-1184. 2. Chen W, Li YS, Gao J, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One, 2016, 11(11): e0166672. |
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质量控制和MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
化学结构
