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N-Benzylpalmitamide

 
Catalog No.
C5619
脂肪酸酰胺水解酶(FAAH)抑制剂
组合的产品项目
规格价格库存 数量
50mg
¥ 2,870.00
Ship with 10-15 days
100mg
¥ 4,550.00
Ship with 10-15 days

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A

背景

N-Benzylpalmitamide is an inhibitor of fatty acid amide hydrolase (FAAH) [1].

The fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH is involved in degrading the fatty acid amide family of endogenous signaling lipids, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to is a member of amidase signature (AS) family. The FAAH integrates into cell membranes and terminates fatty acid amide signaling in vivo [2]. Genetic mutations in FAAH may constitute important risk factors for problem drug use and support a potential link between functional abnormalities in the endogenous cannabinoid system and drug abuse and dependence [3].

N-Benzylpalmitamide was a long-chain fatty acid amide isolated from the maca (L. meyenii) plant and was structurally related to cannabinoids. N-Benzylpalmitamide was a moderate inhibitor of FAAH and inhibited 44% activity of FAAH at 500 μM [1].

References:
[1] Wu H, Kelley C J, Pino-Figueroa A, et al.  Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5188-5197.
[2] Deutsch D G, Ueda N, Yamamoto S.  The fatty acid amide hydrolase (FAAH)[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002, 66(2): 201-210.
[3] Sipe J C, Chiang K, Gerber A L, et al.  A missense mutation in human fatty acid amide hydrolase associated with problem drug use[J]. Proceedings of the National Academy of Sciences, 2002, 99(12): 8394-8399.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt345.6
Cas No.74058-71-2
FormulaC23H39NO
SynonymsN-Benzylhexadecanamide
Solubility≤2mg/ml in organic solvent ethanol
Chemical NameN-(phenylmethyl)-hexadecanamide
SDFDownload SDF
Canonical SMILESO=C(CCCCCCCCCCCCCCC)NCC1=CC=CC=C1
运输条件 蓝冰运输或根据您的需求运输。
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质量控制

质量控制和MSDS

批次:

化学结构

N-Benzylpalmitamide