Montelukast
| 规格 | 价格 | 货期 | 数量 |
|---|---|---|---|
| 100mg | ￥1054.00 | 现货 | |
| 250mg | ￥1554.00 | 现货 |
特色产品
- 适用于流式细胞仪和荧光显微镜检测
- 准确区分活细胞/凋亡细胞/坏死细胞
- 用于免疫印迹和质谱分析等后续操作
- 适用于30 KDa-130 KDa大小的蛋白
- 对细胞无毒性
- 步骤更简单，无需有机溶剂
- 可将信号灵敏度提高100倍
- 同时保持稳定的特异性和分辨率
- 提供更高的转录效率并抑制免疫激活
- 使用5-moUTP和Cy5-utp修饰
- 优异的扩增效率、可重复性和稳定性
- 卓越的灵敏度和准确性，操作简单
- 优化的缓冲液和T7 RNA聚合酶混合物
- 20 μL反应体系可获得更高的RNA产量
产品描述
Montelukast is a potent, selective and orally-active antagonist of the cysteinyl leukotriene 1 (CysLT1) receptor, with an IC50 value of 4.9 nM in HEK293 cell membranes expressing human CysLT1 receptors. The CysLT1 receptor is a receptor for cysteinyl leukotrienes (e.g. LTC4, LTD4, and LTE4) which mediate allergic and hypersensitivity reactions in a variety of inflammatory disorders, in particular asthma. Montelukast has been introduced clinically for the treatment of asthma, allergic rhinitis, and exercise-induced bronchoconstriction.
References:
1. Sarau HM, Ames RS, Chambers J, et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Molecular Pharmacology, 1999, 56(3): 657-663.
2. Storms W. Update on montelukast and its role in the treatment of asthma, allergic rhinitis and exercise-induced bronchoconstriction. Expert Opinion on Pharmacotherapy, 2007, 8(13): 2173-2187.
3.Eum SY, Maghni K, Hamid Q, et al. Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse. American Journal of Respiratory Cell and Molecular Biology, 2003, 28(1): 25-32.
产品性质
| 物理外观 | Solid |
| CAS号 | 158966-92-8 |
| 分子式 | C35H36ClNO3S |
| 分子量 | 586.18 |
| 化学名称 | (R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetic acid |
| 溶解度 | ≥100mg/mL in DMSO; ≥10mg/mL in Ethanol; Insoluble in H2O |
| SMILES | CC(C)(O)C1=CC=CC=C1CC[C@@H](SCC2(CC2)CC(O)=O)C3=CC=CC(/C=C/C4=CC=C5C(C=C(Cl)C=C5)=N4)=C3 |
| 存储条件 | -20°C |
| 运输条件 | 蓝冰 |
产品应用 (实验数据来自文献，APExBIO并未验证，仅供参考)
IC50和靶点
| 生物活性描述 | 孟鲁司特（MK0476 游离碱）是一种强效、选择性和口服活性的半胱氨酰白三烯受体 1（CysLT1）拮抗剂。孟鲁司特可用于哮喘和肝损伤的研究。孟鲁司特还对肠道缺血再灌注损伤有抗氧化作用，并能减轻心脏损伤。孟鲁司特能减少嗜酸性粒细胞对哮喘气道的浸润。孟鲁司特还可用于 COVID-19 研究。 |
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