Montelukast Sodium
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Montelukast钠盐(MK-0476)是一种可逆的白三烯受体的选择性拮抗剂,在U937细胞中的Ki值为0.52 nM[1].
Montelukast钠盐可在U937细胞\豚鼠肺和绵羊肺中抑制白三烯D4受体的特异性结合,Ki值分别为0.52 nM\0.18 nM和4 nM.此外,Montelukast钠盐在U937细胞膜上对白三烯C3抑制效应的IC50值为10 mM,在THP-1细胞膜上对白三烯B4抑制效应的IC50值为40 mM.除此之外,在有意识的松鼠猴中,口服Montelukast钠盐可抑制白三烯D4受体诱发的支气管狭窄,ED50值为0.03±0.001 mg/kg[1].
参考文献：
[1] Jones TR1, Labelle M, Belley M, Champion E, Charette L, Evans J, Ford-Hutchinson AW, Gauthier JY, Lord A, Masson P, et al. Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1995 Feb;73(2):191-201.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 608.17 |
| Cas No. | 151767-02-1 |
| Formula | C35H35ClNNaO3S |
| Solubility | ≥28.7 mg/mL in DMSO; ≥43.6 mg/mL in EtOH; ≥47.5 mg/mL in H2O |
| Chemical Name | sodium;2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)[O-])O.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
