Mevastatin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Mevastatin是一种HMG-CoA还原酶抑制剂,Ki值为1 nM[1].
Mevastatin可逆地抑制HMG-CoA还原酶,与HMG-CoA竞争.该物质Ki值约为1 nM.Mevastatin可在纳摩尔级别的低浓度下在多种细胞中抑制乙酸合成甾醇.该物质也可抑制乙酸掺入,IC50值为1 nM.此外,mevastatin可在1.3 μM下完全抑制L细胞生长.Mevastatin在培养的纤维母细胞中也可影响细胞周期,改变细胞形态[1].
在大鼠中,使用mevastatin可抑制肝脏中甾醇合成,降低血浆胆固醇水平.在家族性高胆固醇血症病人中,mevastatin可有效降低血浆胆固醇.Mevastatin在50 mg/天的剂量下治疗2个月可降低FH杂合病人25%的总胆固醇[1].
参考文献：
[1] Endo A. The discovery and development of HMG-CoA reductase inhibitors. Journal of lipid research, 1992, 33(11): 1569-1582.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 390.51 |
| Cas No. | 73573-88-3 |
| Formula | C23H34O5 |
| Solubility | insoluble in H2O; ≥15.95 mg/mL in DMSO; ≥3.29 mg/mL in EtOH |
| Chemical Name | [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H](C1)C[C@@H](CC[C@@H]2[C@@H]3C(C=C[C@@H]2C)=CCC[C@@H]3OC([C@@H](C)CC)=O)OC1=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
