Melanocyte stimulating hormone release inhibiting factor
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
促黑素释放抑制因子的化学式为C13H24N4O3,是一个三肽,氨基酸序列为H2N-Pro-Leu-Gly-amide,分子量为284.35。促黑素释放抑制因子也被称为Pro-Leu-Gly-NH2、Melanostatin、MSH释放抑制激素或MIF-1,是来源于催产素裂解的内源性多肽片段,在体内通常发挥多种不同的活性(1)。MIF-1产生多种效果,例如阻断阿片受体激活的效应(2)、充当D2和D4多巴胺受体亚型的正向变构调节剂、抑制其他神经肽如α-MSH的释放和增强褪黑素活性(3)。MIF-1对血液代谢具有抗性,可以轻易穿过血脑屏障,它的口服活性较差,通常采用注射的方式用药。
Figure1 Formula of Melanocyte stimulating hormone release inhibiting factor
参考文献:
1. Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America 68 (7): 1428–33.
2. Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences 34 (26): 2559–66.
3. Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 inmovement disorders". The International Journal of Neuroscience 52 (1-2): 59–65.
Physical Appearance | A solid |
Storage | Desiccate at -20°C |
M.Wt | 284.36 |
Cas No. | 2002-44-0 |
Formula | C13H24N4O3 |
Synonyms | Pro-Leu-Gly |
Solubility | ≥59.1 mg/mL in DMSO; ≥50 mg/mL in EtOH; ≥50 mg/mL in H2O |
Chemical Name | (2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
SDF | Download SDF |
Canonical SMILES | CC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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